CASMedChem

THE TOPIC

THE CASMedCHEM strategy

At present only few other platinum complexes have been approved, worldwide or locally, for anticancer therapy, besides cisplatin (namely, carboplatin, oxaliplatin, nedaplatin, lobaplatin, and heptaplatin).

To develop computational strategies to make easier the design of new Pt(II) derivatives more convenient than cisplatin.

In collaboration with
prof. Mauro Ravera
Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale “Amedeo Avogadro” Viale T. Michel 11, 15100 Alessandria (Italy)

Recent papers
Relevance of Polar Surface Area (PSA) in Rationalizing Biological Properties of Several Diamminemalonatoplatinum(II)-derivatives
Giulia Caron, Giuseppe Ermondi, Marzia B. Gariboldi, Elena Monti, Elisabetta Gabano, Mauro Ravera, and Domenico Osella
ChemMedChem, 2009 DOI: 10.1002/cmdc.200900224